For example, matrix metalloproteinase-2 (MMP-2) and MMP-9 are the major proteases correlated to the invasion and metastasis of lung carcinoma; due to their collagen (the main element constructing the basement membrane)-degrading nature, and the greater expression of MMPs in CL1-5 gives the cancer cell a larger potential to destabilize [10,11,12]. This evidence concerns the gene MMP2 and cancer.