BRCA2 and breast carcinoma: Lifetime breast cancer risk is up to 1.2% in male BRCA1 carriers and up to 8.8% in BRCA2 carriers, compared to 0.1% in the general population [4,5]; the lifetime prostate cancer risk is higher in BRCA2 than BRCA1 carriers and the general population, specifically up to 20–25% [6].