Previous studies highlighted the role of lncRNAs with Hippo, transforming growth factor beta (TGFβ)/SMAD, and JAK/STAT signaling pathways [7,35,36] but did not summarize the detailed association with Wnt/β-catenin and PI3K/Akt/mTOR in ESCC. This evidence concerns the gene AKT1 and esophageal squamous cell carcinoma.