Moreover, reverse effects were observed in XAV939 administered TUG1-knockout ESCC cell line, which suggests that the upregulation profile of TUG1 activates the Wnt/β-catenin signaling pathway [15], thus enhancing the proliferation, migration, and invasion and diminishing the apoptosis of ESCC cells. This evidence concerns the gene TUG1 and esophageal squamous cell carcinoma.