Downregulated GASL1 levels increase the protein expression of Wnt3a, β-catenin, and c-Myc and decrease the protein expression of DKK1 [16] (Figure 4), which suggests the activation of the canonical Wnt/β-catenin signaling pathway and ultimately the enhancement of ESCC cell proliferation, migration, and invasion. The gene discussed is MYC; the disease is esophageal squamous cell carcinoma.