Recently, it has been reported that lncRNAs, such as HLA Complex P5 (HCP5), Papillary Thyroid Carcinoma Susceptibility Candidate 1 (PTCSC1), and LINC01014, and the PI3K/Akt/mTOR pathway are in tight conjunction during ESCC pathogenesis. Here, HCP5 is linked to thyroid gland carcinoma.