Recently, it has been reported that lncRNAs, such as HLA Complex P5 (HCP5), Papillary Thyroid Carcinoma Susceptibility Candidate 1 (PTCSC1), and LINC01014, and the PI3K/Akt/mTOR pathway are in tight conjunction during ESCC pathogenesis. The gene discussed is MTOR; the disease is esophageal squamous cell carcinoma.