Furthermore, the administration of an activator (SKL2001) or inhibitor (XAV939) of Wnt/β-catenin signaling pathway to the TUG1-knockout ESCC cell lines EC9706 and OE19 revealed that SKL2001 promoted the expression of N-cadherin, Vimentin, and Snail and abolished the expression of E-cadherin, and thus enhanced the migration and invasion of the ESCC cells [15]. The gene discussed is CDH2; the disease is esophageal squamous cell carcinoma.