In cancer cells, several lncRNAs, such as highly expressed lncRNA in esophageal squamous cell carcinoma (HERES), small nucleolar RNA host gene 16 (SNHG16), urothelial cancer associated 1 (UCA1), maternally expressed 3 (MEG3), LINC00675, HOX antisense intergenic RNA (HOTAIR), taurine upregulated gene 1 (TUG1), and growth-arrest-associated long non-coding R/NA (GASL1), target and affect the expression of β-catenin, a pivotal molecule of the Wnt signaling pathway, which regulates the expression of Wnt target genes and the function of cancer cells in Wnt/β-catenin signaling pathway. The gene discussed is MEG3; the disease is cancer.