GSK3B and cancer: As mentioned in the previous sections, the Wnt/β-catenin and PI3K/Akt/mTOR pathway comprises multiple downstream signaling proteins, such as β-catenin, GSK3-β, Akt, PI3K, and mTORC1 complex, whose activation in association with dysregulated lncRNAs can manifest several hallmarks of cancer, including uncontrolled cell growth, inhibition of apoptosis, proliferation, increased metastasis, and invasion.