LVNC/CHD patients had lower ejection fractions, thickened trabeculations, and worse prognosis when compared with age-matched patients with ventricular septal defectsHeart failure, LV ejection fraction of <24%, LV end-diastolic diameter z-score of >8.56, and the LV NC:C ratio >8.33 at the last visit were risk factors for survival30 genetic variants in 28 patients with LVNC and CHD in the genes (50% sarcomeric): MYH7, TPM1, ACTC1, ANK2, COL4A1, DAAM1, DSG2, DSP, FGF16, FGFR2, HCN4, JUP, MYBPC3, MYH6, MYL2, PKP2, PRDM16, RYR2, and TAZ. The gene discussed is COL4A1; the disease is left ventricular noncompaction.