Furthermore, as displayed on Figure 1, the HTN-related activation of the renin–angiotensin–aldosterone (RAA) cascade and sympathetic nervous system (SNS), in addition to myocardial ischemia in hypertrophic hearts, would also play a major role in the pathogenesis of cardiac arrhythmias in HTN [19,20]. The gene discussed is REN; the disease is hypertensive disorder.