Next to the described SCN5A and SCN10A gene mutation, mutations encoding the cardiac L-type Ca2+ channel alpha subunit, CACNA1c, and the ß-subunit, CACNB2b, as well as alterations in the glycerol-3-phophatedehydrogenase 1-like gene, GPD1-L in the sodium channel ß1 subunit, SCN1B, and in infant death syndrome are considered to be associated with BS and clinical disease [24]. This evidence concerns the gene SCN5A and Bloom syndrome.