Squamous cell carcinoma antigen (SCCA) has been described in the literature as a diagnostic biomarker for squamous cell carcinomas of the uterine, cervix, hepatocellular, esophagus, lung, uterine cervix, head and neck cancer and colon [5,6,7,8] with the possibility of reflecting tumour stage, size, stromal, lymph node and vessel invasion and overall prognosis. The gene discussed is SERPINB3; the disease is neoplasm.