Under hypoxic conditions, astrocytes secrete chemokine C–C motif ligand (CCL) 20, which binds to chemokine C–C motif receptor 6, stimulates the NF-κB signaling pathway, and enhances the expression of HIF-1α in GBM cells, thereby promoting GBM cell invasion and proliferation [114]. This evidence concerns the gene HIF1A and glioblastoma.