Reports discussing NKCC1 mutations reducing its expression and leading to NDs are very recent [10,47,49,50,51,56], as is the established in vivo relationship between specific Trkb deletion from immature DGCs and decreased Nkcc1 expression in a novel mouse model leading to neurodevelopmental disorder and affected cognitive impairment in adult [38]. The gene discussed is NTRK2; the disease is neurodevelopmental disorder.