The GEPIA analysis of the mRNA PTEN mutations expression (logTPM +1) in the immune infiltrates of the TCGA-GBM cohort highlighted the decreased density of B cell naive (p < 1 × 10−15), T cell CD4+ naive (p < 1 × 10−15), T cell CD8+ (p = 0.08), and NK cell (p = 3.97 × 10−9) in the glioma microenvironment compared to GTEx samples. This evidence concerns the gene PTEN and central nervous system cancer.