CD4 and neoplasm: Our Spearman’s correlation tests of immune subpopulations reported a negative correlation (ρ < 0) between PTEN mutations and the expression of infiltrating T cell CD4+ Th 1 (ρ = −0.245), Th 2 (ρ = −0.225), and NK cells (ρ = −0.163) within the tumor microenvironment.