TARDBP and amyotrophic lateral sclerosis: The pathological process underlying ALS is histologically characterized by aggregates of the pathological TDP-43; therefore, the results in the present study suggest that the region of involvement could better indicate the pathophysiological essence of eye movement abnormalities than the type of onset pattern in ALS and provide a more rational explanation for the neural pathways involved and intrinsic pathophysiological mechanism of the disease.