In addition, nimodipine improved symptoms in experimental autoimmune encephalomyelitis (EAE), a common mouse model of MS, fostering remyelination, reducing demyelination, and increasing the number of oligodendrocyte transcription factor (OLIG)2- and adenomatous polyposis coli (APC)-positive oligodendrocytes [23,24]. This evidence concerns the gene APC and experimental autoimmune encephalomyelitis.