ACE2 and infection: Moreover, in a study using K18-hACE2 transgenic mice expressing human ACE2, Netland et al. [81] demonstrated that intranasal infection with SARS-CoV resulted in neuroinvasion through the OB and rapid viral spread to the brain regions connected to the OB, such as the piriform and infralimbic cortices, the basal ganglia, and the midbrain, with significant neuronal death [54,83].