In another study in patients with type 2 diabetes, consumption of a 450 cal (1883 kJ) meal reduced bilateral fMRI activity to visual food cues in the insula; interestingly, this reduction was not observed after a blockade of endogenous GLP-1 activity with GLP-1 receptor antagonist exendin 9–39 [79]. Here, GLP1R is linked to type 2 diabetes mellitus.