As shown in Table 2 and Figure S1, long-term consumption of FCE does not lead to severe side effects such as hepatic failure (evaluated by ALT and AST), renal toxicity (evaluated by CRE and BUN), dysfunction of nutrition (evaluated by ALB), or gout (evaluated by UA), as evidenced by the insignificant changes in these biochemistry analyses. This evidence concerns the gene GPT and Hepatic failure.