In the brain, Alzheimer’s disease and memory-related genes (Camk2n1, Apod, and Serpina3n), and immune-response-related genes (Spp1, CD68, GFAP, Mpeg, Ddx3y, Lyz2, CTSZ, Tyrobp, C4b, and C1qa), were selected for mRNA qPCR analysis in adenine-induced CKD mice. The gene discussed is SPP1; the disease is early-onset autosomal dominant Alzheimer disease.