GSK3B and Alzheimer disease: Recently, an AD model in zebrafish was established by using OA to elucidate the neuroprotective effect of lanthionine ketimine-5-ethyl ester (LKE) and the effects of GSK3β inhibition by 4-benzyl-2-methyl-1, 2, 4-thiadiazolidine-3, 5-dione (TDZD-8) in the context of an AD-like condition [113,114].