Extensive sequence transcriptome analysis performed in samples of hepatocellular carcinoma have identified DARS-AS1 as oncogene positively modulating the expression of Cytoskeleton associated protein 2 (CKAP2), which in turn promotes the expression of two pivotal pathways required for remodeling cytoskeleton derived focal adhesions, focal adhesion kinase (Fak) and extracellular signal-regulated kinases (ERK) [90,91]. The gene discussed is CKAP2; the disease is hepatocellular carcinoma.