Saeed et al. utilized the standard PCE variables in addition to N-terminal pro-hormone B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), and high-sensitivity C-reactive protein (hs-CRP) to predict CAD, stroke, and heart failure events in older adults over a period of four years. The gene discussed is CRP; the disease is stroke disorder.