The other clusters were mostly men with a high proportion of coronary artery disease, dyslipidemia and diastolic dysfunction (HFpEF2), those with the highest BMI, obstructive sleep apnea and poorly controlled diabetes (HFpEF5), and individuals with high rates of AF, elevated BNP and biventricular remodeling (HFpEF6) [14]. The gene discussed is NPPB; the disease is metabolic syndrome.