NELL1 was also found to directly or indirectly act as an important biomarker for many diseases, such as osteoporosis [4,5], metabolic diseases [6,7], neuro-related diseases including bipolar or depression [8,9], inflammatory bowel disease [10], and tumor or tumor-related membranous nephropathy [11,12,13,14]. The gene discussed is NELL1; the disease is neoplasm.