ADGRD1 and glioblastoma: We observed a large boost in signaling when we compared the stimulation with 8E8E8 alone (1.8 μg/ml, 1.4-fold increase, compared to untreated cells) to 8E3E8-conjugated Dynabeads (100 μg/ml, 7.7-fold increase, compared to untreated cells) in GBM cells overexpressing GPR133 (Fig. 7F; F(3,12) = 1.944, p < 0.0001, one-way ANOVA, Tukey’s post hoc test: GPR133-8E3E8: Antibody versus Dyna-Antibody, p < 0.0001).