While many of these sites are not normally associated with active transcription, the overexpression of AR cofactors in prostate cancer is thought to activate expression of pro-proliferative genes at these lower affinity degenerate sites (Chen et al., 2013; Jin et al., 2014; Liu et al., 2017; Mao et al., 2019; Wasmuth et al., 2020). Here, AR is linked to Familial prostate cancer.