PLEKHS1 and gastric cancer: These findings coincided with Chen et al. [18], who reported PLEKHS1 as one of the four genes of the prognostic-protective marker for predicting the overall survival (OS) of GC using univariate, multivariate, and Lasso Cox regression analyses but Zhang et al. [21] showed PLEKHS1 upregulation in the intestinal-type-GC and it was considered as one of a five-gene signature for the disease using The Cancer Genome Atlas (TCGA) database.