On the contrary, CDKN3 was reported as a tumor suppressor in some cancers [11] as it is a negative regulator of Cyclin-dependent kinases (CDK1 and CDK2) [33] but the exact effect of CDKN3 in cancer cell proliferation, either enhancing or precluding, it cannot be explained by its CDK regulation, alone. Here, CDK2 is linked to cancer.