CDKN3 and cancer: These results coincided with Li et al. [20] who showed knockdown of CDKN3 in human GC cells, significantly decreased cancer cell proliferation, invasion, migration, and adhesion leading to cell apoptosis while upregulation of CDKN3 in GC was significantly associated with bad prognosis suggesting that CDKN3 could be a novel therapeutic target in GC treatment.