PLEKHS1 and neoplasm: AADAC gene expression showed high significant (p<0.001) increases in patients with tumor progression signs (tumor size ≥3 cm, ≥3 lymph nodes, higher grades, and higher stages) and a significant (p<0.05) increase in patients with high metastasis (˃ one organ) while PLEKHS1 and CDKN3 gene expressions showed no significant differences in the same patients compared to those with less tumor progression signs as shown in Table 3.