Although previous studies have indicated the significance of inflammasomes in proinflammatory cytokine responses [14–17] and inhibition of the cGAS-mediated interferon signaling in ZIKV monocytes [14], concomitant apoptosis and pyroptosis may benefit the host by removing a shelter for the virus and preventing viral spreading and disseminating, which could be of significance to viral pathogenesis in human ZIKV infections. Here, CGAS is linked to Zika virus infectious disease.