A total of 628 hypermethylated and 592 hypomethylated genes were identified as significant differentially methylated regions (DMRs) using a cut-off of FDR of 5% between the rhesus MSI-H (grouping both sporadic and LS) and MSI-L/MSS (sporadic and one LS tumor) involving some of following genes: PK1B, B4GALT7, GPR35, MYT1L and CYB5D2 (hypermethylated), and GRB10, SOD1, TMSB10 and CD52 (hypomethylated, Fig 3C). Here, CYB5D2 is linked to neoplasm.