In gene set enrichment analysis (31–33), transcripts upregulated in the early COVID-19 mortality cases showed the greatest enrichment for Gene Ontology (GO) terms related to antiviral immune responses, including interferon-gamma-mediated signaling pathway (GO:0060333, 15/68 transcripts, early vs. 4/68 transcripts, late), type I interferon signaling pathway (GO:0060337, 14/65 transcripts, early vs. 4/65 transcripts, late), and defense response to virus (GO:0051607, 10/133 transcripts, early vs. 2/133 transcripts, late). This evidence concerns the gene IFNG and COVID-19.