Increased lung macrophage density in COVID-19 is closely associated with ALI (12, 14, 18, 22), and scRNA-Seq studies show proinflammatory macrophage gene expression signatures in COVID-19 with distinctly high expression of IL-1β and chemokines that may propagate lung inflammation (12, 18, 23, 24). This evidence concerns the gene IL1B and COVID-19.