Interestingly, genetic associations with antibody-based circulating uromodulin at the PRKAG2 and UMOD/PDILT loci shared a very similar pattern of colocalization with numerous kidney-related traits (creatinine, cystatin C, urea, eGFR, CKD, urinary calculus, DBP, SBP, hypertension; Supplemental Table 8 and Figure 3). The gene discussed is CST3; the disease is chronic kidney disease.