UMOD and chronic kidney disease: In order to investigate whether any of the 13 significant loci share phenotype association patterns, and to detect additional disease associations that may be mediated by altered uromodulin levels or properties, we performed colocalization with (i) levels of 30 biomarkers and (ii) 1404 complex traits and diseases based on data from the UK Biobank, as well as (iii) additional traits previously linked to common UMOD variants — namely eGFR, CKD, systolic blood pressure (SBP), diastolic blood pressure (DBP), and uromodulin levels in urine (Methods).