The F98 glioma model has also been used by Barth et al (96) to evaluate the efficacy of radio-iodine therapy, iodine-enhanced synchrotron stereotactic radiotherapy (47, 97), non-invasive MRI to visualize tumor growth (98), diffusion tensor imaging (99), tumor angiogenesis (100), molecular targeting of EGFR (101), and a variety of chemotherapeutic agents, including Nitrone OKN-007 (102), tonabersat, liposomal formulations of carboplatin (103), and TMZ. This evidence concerns the gene EGFR and central nervous system cancer.