As described in our discussion of the F98 glioma, Barth et al (101) have produced and carried out extensive studies with an EGFR and EGFRVIII expressing cell lines, Bryant et al (115) have produced a luciferase expressing cell line of the F98 glioma, and Connolly et al (210) have described the production of genetically engineered PDGF-driven tumor initiation and progression in tv-a transgenic Sprague Dawley rats that replicate key features of human gliomas. Here, EGFR is linked to central nervous system cancer.