Another study evaluated the DNA methylation status of TB patients and their asymptomatic household contacts and found that patients with TB have DNA hypermethylation of the IL-2/STAT5, TNF/NF-κB, and IFN-γ signaling pathways, which demonstrated that TB patients are characterized by DNA hypermethylation of genes critical to mycobacterial immunity (15). This evidence concerns the gene IL2 and tuberculosis.