Furthermore, our comparative bioinformatics analysis of data from Hispanic B-ALL pediatric patients collected from the TARGET database, corroborated the overexpression of PLK1, CDC20, GADD45A, and CDC45 and also agrees with the results of Ma et al. [33] who conducted a pan-cancer study of pediatric cancers, including 689 B-ALL patients enrolled in the Children’s Oncology Group trials. This evidence concerns the gene PLK1 and cancer.