The iDEP tool generated a heatmap with four gene clusters (Fig. 6A) and a network cluster that showed the cell cycle (2e–04) in cluster I, the hematopoietic cell lineage (9e–13) in cluster II, cancer pathways (3e–04) in cluster III, and the Ras 8 (6e–03), MAPK (3e–04), and PI3K-Akt (3e–03) signaling pathways in cluster IV (Fig. 6B). The gene discussed is PIK3CD; the disease is cancer.