Interestingly, the analysis of Hispanic B-ALL patients from the TARGET database corroborated the downregulation of IL7R, which is considered a common driver mutation of ALL [33, 39], but not that of PIK3CG. Our results showed that these B-ALL patients expressed low levels of PIK3CA, PIK3CB, and PIK3CD, which are Class I PI3Ks, such as PIK3CG, PIK3R1, and PIK3R2. Likewise, Ma et al. observed PIK3CA and PIK3R1 as the most frequent mutations in the PI3K and RAS pathways in leukemias. Here, PIK3R2 is linked to leukemia.