The low occurrence of terminal deletions encompassing the FRA3B region in nonpapillary RCC (3 from 100) (Bugert et al. 1997) or normal FHIT transcripts in renal cancer cell lines (van den Berg et al. 1997) lead to the conclusion that FRA3B/FHIT is not involved in the development of nonpapillary RCC. The gene discussed is FHIT; the disease is renal carcinoma.