In a later study, a continuous deletion of a region of chromosome 3p, harboring VHL and FHIT, was found in 96% of ccRCC (Sukosd et al. 2003), which is supported by a number of earlier studies that speculate or imply involvement of the FRA3B region or FHIT in RCC (Hadaczek et al. 1998; Shridhar et al. 1997; Yamakawa et al. 1992). Here, VHL is linked to nonpapillary renal cell carcinoma.