Effectors, many secreted/expressed by the tumour and also the above immunocytes, include immunosuppressive molecules, for example, indoleamine‐2,3‐dioxygenase (IDO), tryptophan‐2,3‐dioxygenase (TDO), arginase, the programmed death receptor ligand 1 (PDL1), cytotoxic T‐lymphocyte‐associated protein 4 (CTLA4), galectin‐1/3/9 and adenosine; immunosuppressive cytokines, for example, IL10, IL23; growth factors and colony stimulating agents (e.g. TGFB,VEGF, CSF1 and CSF2); and chemokines (e.g. CCL2, CXCL1 and CXCL5 (Michielsen et al., 2011). Here, CTLA4 is linked to neoplasm.