Specifically, several studies have demonstrated that GnRH neuron activity or GnRH/LH secretion is increased in animal models of PCOS that recapitulate the three hallmarks of PCOS: the prenatally androgenised (PNA) and the prenatally Anti‐Mullerian hormone treated (PAMH) models of PCOS.58, 59, 60, 61, 62, 63. This evidence concerns the gene GNRH1 and polycystic ovary syndrome.