These included patients affected with different IEI including CVID (14), UAD (3), agammaglobulinemia (3), CID (2), 22q11.2DS (2), WAS post-BMT (2), APDS (1), ataxia telangiectasia (1), hyperIgM (1), immune dysregulation (1), Myd88 deficiency (1), post-HSCT SCID (1), and SIgAD (1). This evidence concerns the gene MYD88 and Ataxia-telangiectasia.