It is known that obesity is associated with the chronic low-grade inflammatory process, not only peripheral but also central, highlighted by increased expression of several inflammatory proteins related to impairments in the hypothalamic signaling of leptin and insulin, such as the suppressor of insulin signaling cytokine 3 (SOCS3) (103, 109, 110). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.