MAVS and infection: Mitochondrial morphology plays an important role on the MAVS-mediated antiviral response originating from this organelle (Castanier et al., 2010): upon infection, mitochondrial MAVS activation allows the induction of the mitochondrial fusion protein mitofusin-1 (MFN1), leading to the organelle’s fusion (Castanier et al., 2010; Onoguchi et al., 2010).