To check the effect of miR-513c-5p on caspase-4, we perform qRT-PCR and Western blot assay upon miR-513c-5p overexpression or inhibition in HUVECs (Supplementary Figures S3A,B), and to check the effect of miR-513c-5p on caspase-11, we conducted the same assay using vascular tissue samples of DVT mice with miR-513c-5p mimics or inhibitor injection (Supplementary Figures S3C,D). The gene discussed is CASP4; the disease is deep vein thrombosis.