Nevertheless, METTL14 expression was also regarded to take pivotal role in normal myelopoiesis and AML pathogenesis, the knockdown of which significantly promoted HSCs differentiation into myeloid cells through SPI1-METTL14-MYB/MYC signaling axis (Weng et al., 2018). The gene discussed is MYC; the disease is acute myeloid leukemia.