Remarkably, several studies have successively demonstrated that the use of spautin-1 in combination with chemotherapy can effectively increase tumor cell mortality and attenuate tumor cell migration and xenotransplantation, both in cell models and animal models, suggesting that spautin-1 may be a potential lead compound targeting USP13 (Zhang et al., 2018; Liao et al., 2019; Guo et al., 2020). This evidence concerns the gene USP13 and neoplasm.