A serological investigation found that all 73 children 1–5 years old from a highly endemic region in Ghana did not show any anti-Ov-103 and Ov-RAL-2 IgE responses, while 3/27 and 1/27 of the children 6–8 years old displayed anti-Ov-103 or Ov-RAL-2 IgE responses, suggesting that continuous exposure to infective larvae in children over 5 years of age may develop IgE response to native Ov-103 and/or Ov-RAL-2 proteins during infection (Abraham et al., 2021). The gene discussed is IGHE; the disease is infection.