The results showed that alanine aminotransferase (ALT) and other liver inflammatory indexes in the lactulose treatment group were significantly reduced compared with the non-alcoholic steatohepatitis model group (P < 0.05), which were established by given high-fat diet, but the steatosis of liver cells was not significantly improved, suggesting that lactulose has a certain role in reducing liver inflammation, but it can’t improve hepatocyte steatosis (Fan et al., 2005). This evidence concerns the gene GPT and steatosis.