Our study findings indicated that CSF-1Rhigh TAMs were significantly correlated with Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, PI3K-Akt signaling pathway, etc. Previous studies have shown that CXC chemokine family and its receptors can regulate tumor behavior by regulating angiogenesis, activating tumor specific immune response and stimulating tumor proliferation in an autocrine or paracrine manner (51). Here, AKT1 is linked to neoplasm.