Using FDR<0.05 and NES>1.5 as cutoffs, we identified 10 signaling pathways that were significantly enriched in high CSF-1R expression, including Cytokine-cytokine receptor interaction, Chemokine signaling pathway, JAK-STAT signaling pathway, Toll-like receptor signaling pathway, B-cell receptor signaling pathway, T-cell receptor signaling pathway, Pathway in cancer, MAPK signaling pathway, VEGF signaling pathway, Colorectal cancer (Table 3 and Figure 4). The gene discussed is CSF1R; the disease is colorectal cancer.