TP53 and neoplasm: Said with his colleagues retrospectively analyzed the response to standard systemic therapy of 145 patients with documented tumor p53 mutational status (mutant-type [mtp53] vs. wild-type [wtp53]), and the results showed that PFS was significantly longer with bevacizumab-containing regimens as compared to non-bevacizumab containing regimen in patients with mtp53 (median 11.0 [95% CI 5.9-16.0], n=22 vs. 4.0 months [95% CI: 3.6-5.7], n=35, P<0.0001), but not those with wtp53 (median 5.0 [95% CI: 2.0-7.6] vs. 6.0 [95% CI 4.0-7.5] months, P=0.318) (77).