TP53 and lung adenocarcinoma: Another study analyzed the data of 491 patients from The Cancer Genome Atlas (TCGA) and demonstrated that co-mutation of EGFRL858R/TP53 increased the expression of COMP and ITGB8, which are involved in an extracellular matrix organization and cell surface receptor signaling pathways, thus contributing to poor prognosis in lung adenocarcinoma.