The results from a phase II study (JMIT) supported this observation as well, showing that pemetrexed + gefitinib improved PFS (15.8 vs 10.9 months, P=0.028) compared with gefitinib alone in East Asian patients with advanced NSCLC and activating EGFR mutations (61). This evidence concerns the gene EGFR and non-small cell lung carcinoma.