Herein, we performed a retrospective study correlating the presence of clinical characteristics, genomic alterations, and PD-L1 expression in Chinese NSCLC patients including ADC and SCC, providing data of the association between PD-L1 expression and genomic features when using different PD-L1 antibodies and in different histological subtypes for identifying potential anti-PD-L1 treatment-related biomarkers in NSCLC. The gene discussed is CD274; the disease is AIDS dementia complex.