Within the aforementioned 464 ADC patients, gene copy gains in PD-L1 and PD-L2 were significantly associated with PD-L1-positive status (p < 0.001 and adj.p = 0.016 and p < 0.001 and adj.p = 0.021, respectively) (Supplementary Table S3). The gene discussed is PDCD1LG2; the disease is AIDS dementia complex.