Pleiotropy Test in the causality of TIMP-3 and IS, ICH., IS = ischemic stroke, LAS = large vessel ischemic stroke, CES = cardioembolic ischemic stroke, SVS = small vessel ischemic stroke, ICH = intracerebral hemorrhage, NLICH = non-lobar intracerebral hemorrhage, LICH = lobar intracerebral hemorrhage. The gene discussed is TIMP3; the disease is intracerebral hemorrhage.