In addition, we also analysed the causal relationship between TIMP-3 and the main subtypes of IS (large artery stroke [LAS], small vessel stroke [SVS], cardioembolic stroke [CES]), and ICH (lobar intracerebral haemorrhage [LICH] and non-lobar intracerebral haemorrhage [NLICH]). The gene discussed is TIMP3; the disease is cat-eye syndrome.