Among TIMPs, TIMP-3 is closely associated with atherosclerosis (Di Gregoli et al., 2017), aneurysm (Di Gregoli et al., 2017), hypertension (Higuchi et al., 2007), and post-ischaemic neuronal injury (Wallace et al., 2002), but its relationship with IS and ICH has not been confirmed. The gene discussed is TIMP3; the disease is hypertensive disorder.