In addition, we also analysed the causal relationship between TIMP-3 and the main subtypes of IS (large artery stroke [LAS], small vessel stroke [SVS], cardioembolic stroke [CES]), and ICH (lobar intracerebral haemorrhage [LICH] and non-lobar intracerebral haemorrhage [NLICH]). Here, TIMP3 is linked to small vessel stroke.