To be specific, we showed that ITGAM, and CCR7 of Neutrophils; TBX21, STAT1, STAT4, and TNF of Th1; CD86 and CSF1R of monocytes; CD163, and VSIG4 of M2 macrophages; CCL2, CD68, and IL10 of TAMs (tumor-associated macrophages); HLA-DPB1, HLA-DRA, HLA-DPA1, CD1C, NRP, and ITGAX of Dendritic cell; GATA3, GATA6, and GATA5A of Th2 were significant correlated with RIMKLB expression in COAD (p < 0.0001; Figures 7A–G) and READ (p < 0.0001; Figures 8A–G). The gene discussed is VSIG4; the disease is colon adenocarcinoma.