The RIMKLB gene mutation was analyzed on COSMIC database comprising more than 2,406 samples of colorectal cancer out of which 77 were recorded for mutations, among them the missense substitution is highest with 53.25% followed by synonymous substitution (23.38%), nonsense substitution (1.30%) and other types (6.49%) (Supplementary Figure S2A). This evidence concerns the gene RIMKLB and colorectal cancer.