NLRP3 inflammasomes are molecular complexes primarily concentrating on the transformation of caspase-1 and caspase-11 into their active forms, which leads to cleavage and activation of IL-1β and IL-18. IL-1β stimulates TF’s release associated with NETs. A cross-talk between NETs and inflammasomes promotes venous thrombosis formation (61). This evidence concerns the gene NLRP3 and Venous thrombosis.