- Frequency of Th2 cells were increased in Ets1ΔCD4 mouse model of SLE - Th2 cells were detected in the kidneys of NZM2410 mouse model of SLE - IL-4 neutralizing antibodies administration or STAT6 deletion in NZM2410 mice resulted in the abrogation of nephritis symptoms - IL-4 transgenic B6C3F1 mice developed glomerulosclerosis associated with collagen deposition. This evidence concerns the gene STAT6 and systemic lupus erythematosus.