- Activated basophils and IgE autoantibodies play role in autoantibody production and lupus nephirtis development in Lyn-/- mice - IgE autoantibodies aggravated disease in FcγRIIB-/-, FcγRIIB-/- (x) Yaa and MRL/Lpr mouse models of SLE. The gene discussed is IGHE; the disease is systemic lupus erythematosus.