We then further investigated the effects of ALKBH5 expression on the tumor immune microenvironment (TIM) of glioma by screening seven metagenes, namely, HCK, IgG, Interferon, LCK, MHC-I, MHC-II, and STAT1, which reflect the status of inflammation and immune responses (48, 49). This evidence concerns the gene HCK and central nervous system cancer.