found that ALKBH5 could regulate the expression of Mct4/Slc16a3 and lactate content in tumor microenvironment, as well as the composition of tumor infiltrating Treg and bone marrow derived inhibitory cells, thereby inhibiting immune cells accumulation in tumor microenvironment in some tumors, which was consistent with our analysis (23). The gene discussed is ALKBH5; the disease is neoplasm.