In recent years, immunotherapy has been widely applied in tumors, but many solid tumors showed poor immunotherapy effect due to their special immunosuppressive microenvironment (49). As an immunologically “cold tumor”, glioma is considered to be highly resistant to immunotherapy. However, our research found that ALKBH5 expression was positively correlated with the infiltration of immune cells into the tumors in glioma and may affect the sensitivity of glioma patients to immunotherapy. The gene discussed is ALKBH5; the disease is central nervous system cancer.