MGMT and central nervous system cancer: Analysis of the TCGA database and the CGGA_325, CGGA_693 datasets showed significantly higher ALKBH5 mRNA levels in the glioma patients with wild-type IDH and chromosomal 1p/19q non-codeletion, and significantly reduced in the glioma patients with MGMT promoter methylation (Supplementary Figures 2A–C).