CPTAC database analysis showed that ALKBH5 protein levels were significantly increased in the ovarian cancer, breast cancer, clear cell renal cell carcinoma (ccRCC), and lung adenocarcinoma tissues, and significantly reduced in the uterine corpus endometrial carcinoma (UCEC) tissues compared with the corresponding normal tissues (Supplementary Figure 3D). The gene discussed is ALKBH5; the disease is nonpapillary renal cell carcinoma.