GEPIA2 database analysis of 33 cancer types showed the following top 10 ALKBH5-related genes: GID4 (R=0.71), TOP3A (R=0.67), MAPK7 (R=0.66), NT5M (R=0.61), FLII (R=0.59), ZNF18 (R=0.57), DRG2 (R=0.57), COPS3 (R=0.56), MED9 (R=0.56) and PRPSAP2 (R=0.56) (all P<0.0001; Figure 4B). This evidence concerns the gene TOP3A and cancer.